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Against Phentermine/Topiramate, Tirzepatide demonstrated a significant association only with dry eye disease (HR 0.29, 95% CI: 0.15–0.57, p = 1.3 × 10 − 4 ), while other outcomes including cataracts (HR 0.76, 95% CI: 0.38–1.52, p = 0.433) and oculomotor binocular dysfunction (HR 0.63, 95% CI: 0.34–1.16, p = 0.134) showed non-significant trends